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    生物材料與藥物技術研究室
      審核人:

    生物材料與藥物技術研究室屬于西北工業大學生命學院,是“空間生物實驗模擬技術國防重點學科實驗室”的重要組成部分。目前,本研究室現有人員24名,其中教授2人、副教授2人、講師3人,博士研究生5人、碩士生12人。研究室承擔包括國家自然科學基金、國家973子課題、國家博士后基金、西北工業大學中央高?;A研究基金等多項科研項目。

    一、 研究方向

    1、生物材料:A. 生物功能材料;B. 生物材料表面修飾;C. 生物制造與仿生

    2、藥物技術:A. 藥物分子設計與活性篩選;B. 靶向緩控釋藥物制劑;C. 特種藥物

    二、團隊成員

    三、科研項目

    1. 國家自然科學基金青年科學基金項目(81803491):雙探針共載腫瘤滲透性納米熒光檢測系統的構建及其在乳腺癌PDT精準治療中的應用,2019.1-2021.12

    2. 國家自然科學基金青年科學基金項目(51801158):多孔鈦表面雙管徑TiO2納米管層的設計及其雙藥控釋抗菌與骨整合,2019. 1-2021.12

    3. 陜西省自然科學基礎研究計劃(2019JQ-320):腫瘤滲透性納米檢測系統在三陰性乳腺癌PDT精準治療中的應用,2019.1-2020.12

    4. 陜西省自然科學基礎研究計劃(2018JQ8018):鈦酸鍶納米管負載LL37的pH響應性控釋抗菌行為及骨整合機制,2018.1-2019.12

    5. 陜西省自然科學基礎研究計劃(2018JQ3071),新型聚多肽基支架的構建及在三維旋轉培養下促進骨再生機制研究,2018.1-2019.12

    6. 中國博士后科學基金面上項目(2018M633584):腫瘤滲透性納米檢測系統對乳腺癌PDT治療的指導研究,2018.5-2020.4

    7. 中國博士后科學基金面上項目(W016343):TiO2納米管負載活性元素及肽的控釋抗菌行為與骨整合,2018.1-2019.12

    8. 中國博士后科學基金面上項目(W016342):模擬微重力下三維培養對干細胞增殖和成骨分化的影響,2018.01-2019.12

    9. 陜西省博士后科研資助項目(2018BSHQYXMZZ43):靶向EGFR智能納米診療系統的構建及其在TNBC精準治療中的應用,2018.11-2020.11

    10. 陜西省自然科學基金項目(2018JM4043):快速修復再生皮膚技術,2018.1-2019.12

    11. 陜西省發展和改革委員會高水平大學建設專項資金項目—生物制造創新平臺項目(0500-17SF0002),2017.5-2018.4

    12. 中央高?;A科研基金項目(3102017OQD051):多孔鈦表面TiO2納米管涂層構建及其骨整合性,2017.1-2018.12

    13. 中央高?;A科研基金項目(31020170QD046):新型聚氨酯/聚脲支架及在三維回轉培養中與MC3T3-E1細胞的作用機制研究,2017.1-2018.12

    14. 中央高?;究蒲袠I務費科研資助項目(3102015ZY085):趨化因子修飾支架材料原位招募自體干細胞及巨噬細胞響應,2015.1-2016.12

    15. 陜西省自然科學基金面上項目(2015JM2067):利魯唑衍生物的合成及其鎮痛作用機制研究,2015.1-2016.12

    16. 陜西省自然科學基礎研究計劃面上項目(2015JM5177):負載生長因子的PLGA基納米纖維材料的研究,2015.1-2016.12

    17. 中央高?;究蒲袠I務費專項資金資助(3102014JKY15005):利魯唑衍生物的合成及其鎮痛作用機制研究,2014.5-2016.5

    18. 國家自然科學基金青年項目(21202130):用于標記糖的熒光探針的設計合成及其示蹤寡糖吸收機制研究,2013.1-2015.12

    19. 國家973課題(2012CB619101):金屬植入材料功能化設計與生物適配機制研究,2012.1-2016.12

    20. 國家自然科學基金青年基金項目(51103116):聚合物膠束與藥物間相容性與增溶作用的相關性及分子機制研究,2012.1-2014.12

    21. 陜西省自然科學基金項目(2010JM2021):正電荷磷脂高分子的設計、合成與性能研究,2010.6-2012.12

    22. 國家科技重大專項重大新藥創制(2009ZX09103-113):MAP-5-FU結腸癌雙靶向候選藥物研究,2009.9-2012.8

    23. 國家自然科學基金面上項目(20872119):親脂性二膦酸鹽的合成及其對失重引起骨丟失的活性研究,2009.1-2011.12

    24. 中央高?;A科研基金(WO18104):親脂性二膦酸鹽對抗空間骨丟失的設計與合成,2008.1-2010.12

    四、研究成果

    雙熒光智能繃帶                      超快速溶解水凝膠敷料

    納米膠水                             強韌型組織粘合劑

    多功能止血海綿膨脹加壓止血(左)和貫通傷止血(右)

    柔性電極

    pH響應性膠束通過擴增腫瘤細胞活性氧誘導細胞凋亡

    pH敏感水凝膠

    說明: 流程圖-20180309

    多孔鈦表面雙管徑納米管涂層及其pH響應性藥物釋放

    說明: C:\Users\張妍妮\AppData\Roaming\Tencent\Users\448721532\QQ\WinTemp\RichOle\%V_W@OP}}D%((}C}BIJ~UEV.png

    骨植入材料的生物學效應

    五、發表論文

    1. H Qi, S Heise, J Zhou, K Schuhladen, Y Yang, S Yang, N Cui, R Dong, S Virtanen, Q Chen, A R Boccaccini, T Lu*. Electrophoretic deposition of bioadaptive drug delivery coatings on magnesium alloy for bone repair, ACS Appl Mater. Interfaces, 2019, 8: 8625-8634.

    2. Cui Ning, Jing Jiajia, Li Meng, Qi Hongfei, Wu Xianglong, Lu Tingli*.Electrophoretic deposition of GHK-Cu loaded MSN-chitosan coatings with pH-responsive release of copper and its bioactivity. Materials Science and Engineering:C, 2019, accepted.

    3. S Heise, C Forster, S Heer, H Qi, J Zhou, S Virtanen, T Lu*, A R. Boccaccini*. Electrophoretic deposition of gelatine nanoparticle/chitosan coatings. Electrochimica Acta, 2019, 307: 318-325.

    4. Dong K, Lei Q, Qi H, Zhang Y, Cui N, Wu X, Xie L, Yan X, Lu T*. Amplification of oxidative stress in MCF-7 cells by a novel pH-responsive amphiphilic micellar system enhances anticancer therapy. Molecular pharmaceutics, 2019, 16(2): 689-700.

    5. Li M, Chen Q, Ma M, Liu X, Dong K, Zhang Y, Lu T*. Electrophoretic deposition of core-shell Ag@MSN incorporated-chitosan coatings with biocompatible and antibacterial activities. Materials Letters, 2019, 239: 29-32.

    6. Q Chen,J Jing,H Qi,I Ahmed,H Yang,X Liu,T Lu*,A R Boccaccini*. Electric field-assisted orientation of short phosphate glass fibers on stainless steel for biomedical applications. ACS Appl. Mater. Interfaces, 2018,10(14): 11529-11538.

    7. Kai Dong, Chunrong Yang, Yan Yan, Pengchong Wang, Ying Sun, Ke Wang, Tingli Lu, Qiang Chen, Yanni Zhang, Jianfeng Xing*, Yalin Dong*. Investigation of the intracellular oxidative stress amplification, safety and anti-tumor effect of a kind of novel redox-responsive micelle. Journal of Materials Chemistry B, 2018, 6(7): 1105-1117.

    8. Yanni Zhang, Ying Chen, Hongchao Kou, Pengfei Yang, Yanen Wang, Tingli Lu, Enhanced bone healing in porous Ti implanted rabbit combining bioactive modification and mechanical stimulation, Journal of the Mechanical Behavior of Biomedical Materials, 2018, 86: 336-344.

    9. H Qi, Q Chen, H Ren, X Wu, X Liu, T Lu*, Electrophoretic deposition of dexamethasone-loaded gelatin nanospheres/chitosan coating and its dual function in anti-inflammation and osteogenesis. Colloids and Surfaces B: Biointerfaces, 2018, 169: 249-256.

    10. Y Zhang, Y Chen, H Kou, P Yang, Y Wang, T Lu*. Enhanced bone healing in porous Ti implanted rabbit combining bioactive modification and mechanical stimulation. Journal of the Mechanical Behavior of Biomedical Materials, 2018, 86:336-344.

    11. Wu X, Liu L, Li Y, Luo J, Gai D, Lu T*, Mei Q*. Synthesis, crystal structure, and antinociceptive effects of some new riluzole derivatives. Medicinal Chemistry Research, 2018, 27(5): 1374-1383.

    12. Ning Cui, Junmin Qian, Jinlei Wang, Chuanlei Ji, Weijun Xu, Hongjie Wang, Preparation, Physicochemical Properties and Biocompatibility of PBLG/PLGA/Bioglass Composite Scaffolds,Materials Science and Engineering: C,2017,71:118-124.

    13. Wang Y, Wang K, Li X, Wei Q, Chai W, Wang S, Che Y, Lu T*, Zhang B*. 3D fabrication and characterization of phosphoric acid scaffold with a HA/beta-TCP weight ratio of 60: 40 for bone tissue engineering applications, PLoS ONE, 2017, 12(4): 1-14.

    14. Zhang Yanni#, Zhang Lan, Li Bo, Han Yong*, Enhancement in sustained release of antimicrobial peptide from dual-diameter structured TiO2 nanotubes for long-lasting antibacteria and cytocompatibility, ACS Applied Materials & Interface, 2017, 9: 9449-9461.

    15. Zhang Yanni#, Han Yong*, Zhang Lan, Formation and bioactivity of SrTiO3 nanotubes on titanium by modified anodization and hydrothermal treatment, Journal of Materials Science & Technology, 2016, 32: 930-936.

    16. H Qi, Z Ye, H Ren, N Chen, Q Zeng, X Wu, T Lu*. Bioactivity assessment of PLLA/PCL/HAP electrospun nanofibrous scaffolds for bone tissue engineering. Life Sciences, 2016, 148: 139-144.

    17. Ning Cui, Junmin Qian, Weijun Xu, Minghui Xu, Na Zhao, Ting Liu, Hongjie Wang, Preparation, Characterization, and Biocompatibility Evaluation of Poly(N-acryloyl-l-lysine)/Hyaluronic Acid Interpenetrating Network Hydrogels, Carbohydrate Polymers,2016,136:1017-1026.

    18. Chen, Qiang, Li, Wei, Yao, Qingqing, Liang, Ruifang, Pérez-Garcia Rosalina, Munoz, Josemari, Boccaccini Aldo R.. Multilayered drug delivery coatings composed of daidzein-loaded PHBV microspheres embedded in a biodegradable polymer matrix by electrophoretic deposition. Journal of Materials Chemistry B. 2016, 4(29): 5035-5045.

    19. Ning Cui, Junmin Qian, Jinlei Wang, Yaping Wang, Weijun Xu, Hongjie Wang, Physicochemical Properties and Biocompatibility of PZL/PLGA/Bioglass Composite Scaffolds for Bone Tissue Engineering, RSC Advances,2016, 6:97096-97106.

    20. Ning Cui, Junmin Qian, Jinlei Wang, Chuanlei Ji, Weijun Xu, Hongjie Wang, Preparation and Characterization of Foamy Poly(γ-benzyl-L-glutamate-co-L-phenylalanine)/Bioglass Composite Scaffolds for Bone Tissue Engineering, RSC Advances,2016,6:73699-73708.

    21. Song Jiankang, Chen Qiang, Zhang Yang, Mani Diba, Eva Kolwijck, Shao Jinlong, John A. Jansen, Fang Yang, Aldo R. Boccaccini, Sander C. G. Leeuwenburgh. Electrophoretic deposition of chitosan coatings modified with gelatin nanospheres to tune the release of antibiotics. ACS applied materials & interfaces, 2016, 822: 13785-13792.

    22. Wen Zhao, Jiaojiao Li, Kaixiang Jin, Wenlong Liu, Xuefeng Qiu, Chenrui Li, Fabrication of functional PLGA-based electrospun scaffolds and their applications in biomedical engineering. Materials Science & Engineering C, 2016, 59:1181-1194.

    23. Qi Hongfei, Ye Zhihong, Ren Hailong, Chen Nana, Zeng Qingyan, Wu Xianglong,Lu Tingli. Bioactivity assessment of PLLA/PCL/HAP electrospun nanofibrous scaffolds for bone tissue engineering. Life sciences, 2016, 148: 139-144.

    24. Dong K, Yan Y, Wang PC, Shi XP, Zhang L, Wang K, Xing JF, Dong YL. Biodegradable mixed MPEG-SS-2SA/TPGS micelles for triggered intracellular release of paclitaxel and reversing multidrug resistance. International Journal of Nanomedicine. 2016, 11: 5109-5123.

    25. Dong K, Zhang HF, Yan Y, Sun JY, Dong YL, Wang K, Zhang L, Shi XP, Xing JF. Improvement of side-effects and treatment on the experimental colitis in mice of a resin microcapsule loading hydrocortisone sodium succinate. Drug Development and Industrial Pharmacy. 2016, 15: 448-457.

    26. Dong K, Zeng AG, Wang ML, Dong YL, Wang K, Guo CN, Yan Y, Zhang L, Shi XP, Xing JF. In vitro and in vivo study of a colon-targeted resin microcapsule loading a novel prodrug, 3, 4, 5-tributyryl shikimic acid. RSC Advances. 2016, 6: 16882-16890.

    27. Dong K, Dong YL, You CY, Xu W, Huang XY, Zhang L, Wang K, Xing JF. Assessment of the drug loading, in vitro and in vivo release behavior of novel pH-sensitive hydrogel. Drug Delivery. 2016, 23(1): 174-184.

    28. 景佳佳,武祥龍,盧婷利.膠原三肽及其生物應用的研究進展.生命科學. 2016, 28(9): 1-7.

    29. 席朵,盧婷利.巨噬細胞起源及自我更新的研究進展.現代免疫學. 2016, 36(5):415-419.

    30. Qiang Chen, Wei Li, Ourania-Menti Goudouri, Yaping Ding, Sandra Cabanas-Polo, and Aldo R. Boccaccini. Electrophoretic deposition of antibiotic loaded PHBV microsphere-alginate composite coating with controlled delivery potential.Colloids and Surfaces B: Biointerfaces, 2015, 130: 199-206.

    31. Qiang Chen, Sandra Cabanas-Polo, Yaping Ding, Aldo. R. Boccaccini, Bioactive glass-biopolymer multilayer coatings fabricated by electrophoretic deposition combined with layer-by-layer assembly. Key Engineering Materials, 2015, 654: 170-175.

    32. Ning Cui, Junmin Qian, Ting Liu, Na Zhao, Hongjie Wang, Hyaluronic Acid Hydrogel Scaffolds with a Triple Degradation Behavior for Bone Tissue Engineering, Carbohydrate Polymers,2015,126:192-198.

    33. Wen Zhao, Wenlong Liu, Jiaojiao Li, Xiao Lin, Ying Wang. Preparation of animal polysaccharides nanofibers by electrospinning and their potential biomedical applications.Journal of Biomedical Materials Research: Part A, 2015, 103: 807-818.

    34. Zhang Yanni#, Han Yong*, Zhang Lan, Interfacial structure of the firmly adhered TiO2nanotube films to titanium fabricated by a modified anodization, Thin Solid Films, 2015, 583: 151-157.

    35. Zhang Yanni#, Han Yong*, Zhang Lan, Characterization of Zn-Doped TiO2Nanotubes Anodized on Titanium Surface, Rare Metal Materials and Engineering, 2014, 4: 68-71.

    36. Ning Cui, Junmin Qian, Na Zhao, Hongjie Wang, Functional Hyaluronic Acid Hydrogels Prepared by a Novel Method, Materials Science and Engineering: C,2014,45:573-577.

    37. Qiang Chen, Liu Yufang, Yao Qingqing, Yu Shanshan, Zheng Kai, Pischetsrieder, Monika, A. R. Boccaccini. Multilayered bioactive composite coatings with drug delivery capability by electrophoretic deposition combined with layer-by-layer deposition.Advanced Biomaterials and Devices in Medicine1 2014, 35: 18-27.

    38. Qiang Chen, Uxua Pérez de Larraya, Nere Garmendia, María Lasheras-Zubiate, Luis Cordero-Arias, Sannakaisa Virtanen, Aldo R. Boccaccini. Electrophoretic deposition of cellulose nanocrystals (CNs) and CNs/alginate nanocomposite coatings and free standing membranes.Colloids and Surfaces B: Biointerfaces, 2014, 118: 41-48.

    39. Qiang Chen, Sandra Cabanas-Polo, Ourania-Menti Goudouri, Aldo R. Boccaccini. Electrophoretic co-deposition of polyvinyl alcohol (PVA) reinforced alginate–Bioglass? composite coating on stainless steel: Mechanical properties and in-vitro bioactivity assessment.Materials Science and Engineering: C, 2014, 40: 55-64.

    40. Tingli Lu, Ting Chen, Yuankun Zhai, Yufan Ma, Yuehong Xiao. Designer Functionalized Self-Assembling Peptide Scaffolds for Adhesion, Proliferation, and Differentiation of MC3T3-E1.Soft Materials. 2014, 12, 79-87.

    41. X. L. Wu, W.T. Fan, Y. L. Pan, et al. Synthesis, crystal structure and anti-fatigue effects of some benzamide derivatives.Molecules. 2014, 19: 1034-1046.

    42. X. L. Wu, W.T. Fan, Y. L. Pan, et al. Synthesis, spectroscopic properties, and biological applications of eight novel chlorinated fluorescent proteins-labeling probes.Journal of Fluorescence. 2014, 24(3):775-786.

    43. Dong K, Dong YL, You CY, Xu W, Huang XY, Yan Y, Zhang L, Wang K, Xing JF. Assessment of the safety, targeting, and distribution characteristics of a novel pH-sensitive hydrogel.Colloid and Surface B-Biointerfaces. 2014, 123: 965-973.

    44. Tingli Lu, Yuhui Li, Tao Chen. Techniques of Fabrication and Construction Three-dimensional Scaffolds for Tissue Engineering.International Journal of Nanomedicine. 2013, 8: 337-350.

    45. Tingli Lu,Yuhui Li, Yunqing Wang, et al. Preparation and characterization of porous nano-sized hydroxyapatite/collagen composite as bone scaffold. Advanced Materials Research. 2013, 647: 62-66.

    46. Wen Zhao, Hong Zhang, TingLi Lu, Wenlong Liu. Electrostatic self-assembly: an innovative approach to fabricate novel-structured magnetic liposomes. Applied Surface Science, 2013, 265: 101-107.

    47. Wen Zhao, Wenlong Liu. Compatibility between Paclitaxel and Polymer Carrier.Applied Mechanics and Materials. 2013,420: 263-268.

    48. Dong K, Xu W, You CY, Xing JF, Zhang JY, Gao Y, Wang K. Novel Biodegradable pH/Thermosensitive Hydrogels: Part 1. Preparation and Characterization.International Journal of Polymeric Materials and Polymeric Biomaterials.2013, 62(14): 726-732.

    49. 陳婷,盧婷利,馬玉樊,王韻晴,校月紅,李昱輝.三維多肽支架中前成骨細胞MC3T3-E1成骨分化的初步研究.材料導報, 2013, 27(2): 48-51.

    50. Qiang Chen, Luis Cordero-Arias, Judith A. Roether, Sandra Cabanas-Polo, Sannakaisa Virtanen, Aldo R. Boccaccini. Alginate/Bioglass? composite coatings on stainless steel deposited by direct current and alternating current electrophoretic deposition. Surface and Coatings Technology, 2013, 233: 49-56.

    51. Tingli Lu, Zhao Wang, Yufan Ma, Yang Zhang, Tao Chen. Influence of polymer size, liposome composition, surface charge and temperature on the permeability of pH-sensitive liposomes containing lipid-anchored poly(2-ethylacrylic acid).International Journal of Nanomedicine. 2012, 7: 4917–4926.

    52. 王韻晴,盧婷利,陳婷,馬玉樊,趙雯,陳濤.自組裝多肽支架材料的研究進展.材料科學與工程學報. 2012, 311 (02): 324-328.

    53. 孔丹鳳,趙雯,張軍平,盧婷利,陳濤.計算機模擬對嵌段共聚物膠束結構的優化設計,材料科學與工程學報, 2012, 30(2): 1-5.

    54. 陳濤,王汝濤,胡惠靜,傅經國,盧婷利.丙泊酚制劑引起注射部位疼痛的機制研究進展,國際麻醉學與復蘇雜志. 2012, 32(1):109-112.

    55. 胡惠靜,陳濤,王汝濤,盧婷利.丙泊酚注射疼痛及其預防措施研究進展,醫藥導報. 2012, 31(1):63-66.

    56. Tingli Lu, Weiguang Sun, Wen Zhao, Tao Chen. Preparation of amifostine polylactide–co-glycolide microspheres and its irradiation protection in mouse through oral administration. Drug Development and Industrial Pharmacy. 2011, 37(12): 1473-1480.

    57. Tingli Lu, Yufan Ma, Huijing Hu, Yun Chen, Wen Zhao, Tao Chen. Ethinylestradiol liposome preparation and its effects on ovariectomized rats’ osteoporosis, Drug Delivery. 2011, 18(7): 468-477.

    58. Tingli Lu, Huijing Hu, Wen Zhao, Tao Chen. Synthesis and in vivo bioactivity of lipophilic alendronate derivatives against osteoporosis. Drug Development and Industrial Pharmacy. 2011, 37(6): 656-663.

    59. X Wu, X Jin, Y Wang, Q Mei, J Li, Z Shi, Synthesis and spectral properties of novel chlorinated pH fluorescent probes. Journal of Luminescence. 2011, 131(4): 776-780.

    60. 馬玉樊,盧婷利,王韻晴,趙雯,梅其炳,陳濤.氫青蒿素對人成骨肉瘤MG-63細胞凋亡的誘導作用.中國細胞生物學學報. 2011, (12): 1324-1330.

    61. 陳婷,盧婷利,王韻晴,校月紅,李昱輝.多肽自組裝及其在生物醫學中的應用,材料導報. 2011, (19):90-95.

    62. 王韻晴,盧婷利,趙雯,惠倩倩,孔丹鳳,陳濤.骨組織工程支架材料的研究進展.材料導報, 2011,(03):125-131.

    63. 盧婷利,張宏,王韻晴,惠倩倩,趙雯.組織工程支架材料生物功能化的研究進展,材料科學與工程學報, 2011,(02): 301-307.

    64. 張志剛,盧婷利,惠倩倩,趙雯,高劍利,陳濤.二膦酸鹽去氫膽?;苌锏脑O計、合成及分析,中國醫院藥學雜志. 2011,31(9): 5-8.

    65. 孔丹鳳,趙雯,盧婷利,惠倩倩,王韻晴,陳濤.分子印跡技術在藥物分離中的研究進展,藥學實踐雜志. 2011,29(3):161-164.

    66. 李昱輝,盧婷利.組織工程支架材料的研究進展,中國材料科技與設備. 2011,7(5): 15-18.

    67. 張緒君,盧婷利,陳濤,高迎春,趙雯.注射藥物微球的表面修飾研究進展,中國藥業. 2011,20(15): 1-3.

    68. Lu Ting Li, Hu Hui Jing, Zhao Wen, Chen Tao. RP-HPLC analysis of hydrophobic alendronate amidated derivatives. Journal of Liquid Chromatography & Related Technologies, 2010,33(3): 349-361

    69. Tingli Lu, Cui Fuxing. Synthesis and Properties of Non-functional Cubic Silsesquioxane Macromonomers. Designed Monomers and Polymers, 2010, 13(1): 73-85.

    六、發明專利

    1. 可快速降解的強韌型水凝膠傷口敷料及其制備方法.中國發明專利, 201811606618.7

    2. 適用于動態組織表面高強度粘合的多功能水凝膠粘合劑及其制備方法.中國發明專利, 201811541713.3

    3. 一種功能化介孔氧化硅、及其制備和在傷口修復中的應用方法,中國發明專利, CN201810602708.2

    4. 一種納米片組裝的花狀磷酸鈦微球及其制備方法,中國發明專利, CN201810143744.7

    5. 一種富含維生素的高能營養脂肪乳凍干粉及制備方法.國防發明專利. ZL 201318006417.5

    6. 一種富含***凍干粉及制備方法.國防發明專利. ZL 201318006417.5

    7. 一種富含***凍干粉及制備方法.國防發明專利. ZL 201318006417.5

    8. 具有***藥理活性化合物的制備及其使用方法.國防發明專利. ZL 201318006415.6

    9. 具有促成骨生長的生物活性多肽及其制備方法,中國發明專利, 201210160277.1

    10. 單甲氧基聚乙二醇-聚L-色氨酸兩親性嵌段共聚物及其制備方法以及其載藥膠束溶液的制備方法.中國發明專利, ZL 201110132965.2

    11. 苯甲酰胺化合物及其制備方法.中國發明專利, ZL 201110148165.X

    12. 蒿甲醚/本芴醇復方脂肪乳靜脈注射劑及其制備方法.中國發明專利, ZL 201010216610.7

    13. 二膦酸鹽衍生物的制備方法.中國發明專利, ZL 200610105179.2

    14. 淫羊霍提取物脂肪乳組合物及其制備方法.中國發明專利, ZL 200610105343.X.

    15. 雌激素脂質體的制備方法.中國發明專利, ZL 200710017233.2

    16. 磁性脂質體及其制備方法.中國發明專利, ZL 200910022717

    17. 甲氟喹脂肪乳組合物及其制備方法.中國發明專利, ZL 200910020907

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