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    化學生物學與分子工程研究室
      審核人:

    本研究室現有教授1名(牛衛寧),副教授2名(徐春蘭,尚曉婭),博士生導師2名(牛衛寧,徐春蘭),碩士生導師1名(尚曉婭),在讀博士、碩士研究生共20人。主持國家自然科學基金6項、陜西省重點研發計劃等省部級課題7項以及其它各類課題20余項。授權國家發明專利6項,發表論文30余篇。獲得陜西省科學技術三等獎和西安市科學技術二等獎各1項。 

    研究方向一

    ● 細胞硫/H2S代謝機制及其對能量代謝的影響

    ● 細胞硫/H2S代謝與腫瘤發生機制的研究及其藥物篩選

    研究方向二

    生物活性多肽的功能研究。

    ● 神經肽介導的微生物-腦-腸軸對腸道屏障功能的調控機制

    ● 動物源性防御肽-必需微量元素-益生菌類復合微生態制劑的研制

    ● 線粒體靶向肽影響細胞能量代謝的機制

    研究方向三

    糖生物學研究。

    ● 多糖分子結構和功能、構效關系及生物活性機制研究

    ● 活性寡糖維護機體健康的機理研究

    研究方向四

    ●生物催化合成藥物中間體

    ●醫療診斷用酶的產業化制備

    科研項目

    主持國家自然科學基金面上項目3項(項目編號:31871145;31672435;31471086);

    主持國家自然科學基金青年項目3項;

    主持陜西省重點研發計劃項目2項;

    主持陜西省科技攻關項目3項;

    主持企業橫向課題、中央高?;究蒲袠I務費等其它項目10余項。

    近期代表性論文

    [1]Niu WN*, Wang J, Qian J, Wang MY, Wu P, Chen F, Yan SS. Allosteric control of human cystathionineβ-synthase activity by a redox active disulfide bond.J. Biol. Chem.2018, 293(7):2523-2533

    [2]Niu WN*, Chen F, Wang J, Qian J, Yan SS. Antitumor effect of sikokianin C, a selective cystathionineβ-synthase inhibitor, against human colon cancerin vitroandin vivo.Med Chem Commun. 2018, 9:113-120

    [3]Niu WN*, Cao SS, Yang ML, Xu L. Enzymatic Synthesis of S-Adenosylmethionine Using Immobilized Methionine Adenosyltransferase Variants on the 50-mM Scale.Catalysts2017, 7(8), 238.

    [4]Niu WN*, Wu P, Chen F, Wang J, Shang XY, Xu CL. Discovery of selective cystathionineβ-synthase inhibitors by high-throughput screening with a fluorescent thiol probe.Med Chem Commun. 2017, 8:198-201

    [5]Niu WN,Yadav PK, Adamec J, Banerjee R*. S-Glutathionylation Enhances Human Cystathionine-β- synthase Activity Under Oxidative Stress Conditions.Antioxid Redox Signal. 2015, 22(5): 350-361 (封面論文)

    [6]Chunlan Xu* , Yu Guo,Lei Qiao,Li Ma,Yi-yi Cheng. Preparation, characteristics and antioxidant activity of polysaccharides and proteins-capped selenium nanoparticles synthesized byLactobaccillus caseiATCC 393.Carbohydrate Polymers. 2018, 195: 576-585.

    [7]Chunlan Xu* , Yu Guo,Lei Qiao,Li Ma,Yiyi Cheng, Alexandra Roman. Biogenic synthesis of novel functionalized selenium nanoparticles byLactobacillus casei393 and its protective effects on intestinal barrier dysfunction caused by EnterotoxigenicEscherichia coliK88.Frontiers in Microbiology. 2018, 9: 1129.

    [8]Chunlan Xu* , Yu Guo,Lei Qiao,Li Ma,Yiyi Cheng. Recombinant vasoactive intestinal peptide analogue ameliorates TNBS-induced colitis in rats.World Journal of Gastroenterology. 2018,24(6):706-715.

    [9]Chunlan Xu*,Yu Guo,Xiangjin Qiao,Xiaoya Shang,Weining Niu,Mingliang Jin*,Design, recombinant fusion expression and biological evaluation of vasoactive intestinal peptide analogue as novel antimicrobial agent. Molecules. 2017, 22:1963.

    [10]Chunlan Xu,Sally Ghali,Jiani Wang,et al. CSA13 inhibits colitis-associated intestinal fibrosis via a formyl peptide receptor like-1 mediated HMG-CoA reductase pathway. Scientific Reports. 2017, 7:16351

    [11]Chunlan Xu*,XJ Qiao, Y.F.Zhao, R.Sun, X.Y.Shang, W.N.Niu.Resveratrol ameliorates chronic high altitude exposure-induced oxidative stress and lipid metabolism alteration in rats.European Journal of Lipid Science and Technology. 2016, 118:612-621.

    [12]Chunlan Xu*,Youming Wang; Rui Sun,Xiangjin Qiao,Xiaoya Shang,Weining Niu,Modulatory Effects of Vasoactive Intestinal Peptide on Intestinal Mucosal Immunity and Microbial Community of Weaned Piglets Challenged by an EnterotoxigenicEscherichia coli(K88).PLos One. 2014, 9(8):e104183.

    [13]Chunlan Xu*, R.Sun, XJ Qiao, C.C.Xu, X.Y.Shang, W.N.Niu,Protective effect of glutamine on intestinal injury and bacterial community in rats exposed to hypobaric hypoxia environment.World Journal of Gastroenterology. 2014, 20(16): 4467-4838.

    [14]Chunlan Xu*, R.Sun, XJ Qiao, C.C.Xu, X.Y.Shang, W.N.Niu, Y. Chao,Effect of vitamin E supplementation on intestinal barrier function in rats exposed to high altitude hypoxia environment.Korean Journal of Physiology & Pharmacology. 2014,18:1-8.

    [15]Chunlan Xu*, C.Dong, C.C.Xu, T.T. Han, S.Bao, X.B.Gao. Effect of iron glycinate chelate on the expression of hypoxia-inducible factor and antioxidant status in rats exposed to high altitude hypoxia environment.Biological Trace Element Research. 2014, 162:142-152.

    [16]Shang XY*, Chao Y, Zhang Y, Lu CY, Xu CL, Niu WN. Immunomodulatory and antioxidant effects of polysaccharides from Gynostemma pentaphyllum Makino in immunosuppressed Mice.Molecules, 2016, 21 (8): 1085.

    [17]Jiani Wang, Sally Ghali,Chunlan Xu, et al. Ceragenin CSA13 reduces Clostridium difficile infection in mice by modulating the intestinal microbiome and metabolites.Gastroenterology. 2018, 154(6): 1737-1750.

    [18]Hon Wai Koon, Bowei Su,Chunlan Xu, et al. ProbioticSaccharomyces boulardiiCNCM I-745 prevents outbreak-associatedClostridium difficile-associated cecal inflammation in hamsters.American Journal of Physiology- Gastrointestinal and Liver Physiology. 2016, 311(4):G610-G623.

    [19] Gherasim C, Yadav PK, Kabil O,Niu W-N, Banerjee R, Nitrite Reductase Activity and Inhibition of H2S Biogenesis by Human Cystathionine ?-Synthase.PLoS ONE, 2014, 9(1): e85544

    聯系方式

    牛衛寧,教授,博導,E-mail:niuweining@nwpu.edu.cn

    徐春蘭,副教授,博導,E-mail:clxu@nwpu.edu.cn

    尚曉婭,副教授,碩導,E-mail:loyamuyu@nwpu.edu.cn

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    地址:陜西省西安市友誼西路127號西北工業大學  聯系電話:029-88460332  傳真:029-88460332
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